AATK

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Apoptosis-associated tyrosine kinase
Identifiers
Symbols AATK ; AATYK; AATYK1; LMR1; LMTK1; PPP1R77; p35BP
External IDs OMIM605276 MGI1197518 HomoloGene74861 IUPHAR: 1922 GeneCards: AATK Gene
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez 9625 11302
Ensembl ENSG00000181409 ENSMUSG00000025375
UniProt Q6ZMQ8 Q80YE4
RefSeq (mRNA) NM_001080395 NM_001198785
RefSeq (protein) NP_001073864 NP_001185714
Location (UCSC) Chr 17:
79.09 – 79.14 Mb
Chr 11:
120.01 – 120.05 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[1][2][3]

Structure and expression[edit]

The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.[1][2]

Function[edit]

The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the c-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[4][3] Its suppressive role on melanoma development has been reported recently. [5]

AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.[6]

References[edit]

  1. ^ a b Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H et al. (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ a b Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T et al. (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization". Journal of Human Genetics 44 (2): 141–2. doi:10.1007/s100380050130. PMID 10083745. 
  3. ^ a b "Entrez Gene: AATK apoptosis-associated tyrosine kinase". 
  4. ^ Kos A, Olde Loohuis NF, Wieczorek ML, Glennon JC, Martens GJ, Kolk SM et al. (2012). "A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase". PloS One 7 (2): e31022. doi:10.1371/journal.pone.0031022. PMC 3281898. PMID 22363537. 
  5. ^ Ma S, Rubin BP (Apr 2014). "Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma". Laboratory Investigation; A Journal of Technical Methods and Pathology 94 (4): 430–438. doi:10.1038/labinvest.2014.13. PMID 24589855. 
  6. ^ Gagnon KB, England R, Diehl L, Delpire E (May 2007). "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation". American Journal of Physiology. Cell Physiology 292 (5): C1809. doi:10.1152/ajpcell.00580.2006. PMID 17267545. 

Further reading[edit]

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954. 
  • Raghunath M, Patti R, Bannerman P, Lee CM, Baker S, Sutton LN et al. (May 2000). "A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line". Brain Research. Molecular Brain Research 77 (2): 151–62. doi:10.1016/S0169-328X(00)00048-6. PMID 10837911. 
  • Tomomura M, Hasegawa Y, Hashikawa T, Tomomura A, Yuzaki M, Furuichi T et al. (Apr 2003). "Differential expression and function of apoptosis-associated tyrosine kinase (AATYK) in the developing mouse brain". Brain Research. Molecular Brain Research 112 (1-2): 103–12. doi:10.1016/S0169-328X(03)00054-8. PMID 12670708. 
  • Honma N, Asada A, Takeshita S, Enomoto M, Yamakawa E, Tsutsumi K et al. (Oct 2003). "Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein". Biochemical and Biophysical Research Communications 310 (2): 398–404. doi:10.1016/j.bbrc.2003.08.143. PMID 14521924. 
  • Piechotta K, Garbarini N, England R, Delpire E (Dec 2003). "Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase". The Journal of Biological Chemistry 278 (52): 52848–56. doi:10.1074/jbc.M309436200. PMID 14563843. 

External links[edit]