AATK

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Apoptosis-associated tyrosine kinase
Identifiers
Symbols AATK ; AATYK; AATYK1; LMR1; LMTK1; PPP1R77; p35BP
External IDs OMIM605276 MGI1197518 HomoloGene74861 GeneCards: AATK Gene
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez 9625 11302
Ensembl ENSG00000181409 ENSMUSG00000025375
UniProt Q6ZMQ8 Q80YE4
RefSeq (mRNA) NM_001080395 NM_001198785
RefSeq (protein) NP_001073864 NP_001185714
Location (UCSC) Chr 17:
79.09 – 79.14 Mb
Chr 11:
120.01 – 120.05 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.[1][2][3]

Structure and expression[edit]

The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.[1][2]

Function[edit]

The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the c-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.[4][3] Its suppressive role on melanoma development has been reported recently. [5]

AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.[6]

References[edit]

  1. ^ a b Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ a b Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization". J Hum Genet 44 (2): 141–2. doi:10.1007/s100380050130. PMID 10083745. 
  3. ^ a b "Entrez Gene: AATK apoptosis-associated tyrosine kinase". 
  4. ^ Kos, A.; Olde Loohuis, N. F. M.; Wieczorek, M. L.; Glennon, J. C.; Martens, G. J. M.; Kolk, S. M.; Aschrafi, A. (2012). "A Potential Regulatory Role for Intronic microRNA-338-3p for Its Host Gene Encoding Apoptosis-Associated Tyrosine Kinase". PLoS ONE 7 (2): e31022. doi:10.1371/journal.pone.0031022. PMID 22363537.  edit
  5. ^ Ma S (Apr 2014). "Apoptosis-associated tyrosine kinase 1 inhibits growth and migration and promotes apoptosis in melanoma.". Lab Invest. 94 (4): 430–438. doi:10.1038/labinvest.2014.13. PMID 24589855. 
  6. ^ Gagnon, K. B. E.; England, R.; Diehl, L.; Delpire, E. (2006). "Apoptosis-associated tyrosine kinase scaffolding of protein phosphatase 1 and SPAK reveals a novel pathway for Na-K-2C1 cotransporter regulation". AJP: Cell Physiology 292 (5): C1809. doi:10.1152/ajpcell.00580.2006.  edit

Further reading[edit]

External links[edit]