AATK

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Apoptosis-associated tyrosine kinase
Identifiers
Symbols AATK ; AATYK; AATYK1; LMR1; LMTK1; p35BP
External IDs OMIM605276 MGI1197518 HomoloGene74861 GeneCards: AATK Gene
EC number 2.7.11.1
Orthologs
Species Human Mouse
Entrez 9625 11302
Ensembl ENSG00000181409 ENSMUSG00000025375
UniProt Q6ZMQ8 Q80YE4
RefSeq (mRNA) NM_001080395 NM_001198785
RefSeq (protein) NP_001073864 NP_001185714
Location (UCSC) Chr 17:
79.09 – 79.14 Mb
Chr 11:
120.01 – 120.05 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase LMTK1 is an enzyme that in humans is encoded by the AATK gene.[1][2][3]

Function[edit]

AATK is a novel gene which is induced during apoptosis. It encodes a protein with a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. AATK expression may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells.[3]

References[edit]

  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Seki N, Hayashi A, Hattori A, Kozuma S, Ohira M, Hori T, Saito T (Apr 1999). "Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization". J Hum Genet 44 (2): 141–2. doi:10.1007/s100380050130. PMID 10083745. 
  3. ^ a b "Entrez Gene: AATK apoptosis-associated tyrosine kinase". 

Further reading[edit]

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