ABCA2

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ATP-binding cassette, sub-family A (ABC1), member 2
Identifiers
Symbols ABCA2 ; ABC2
External IDs OMIM600047 MGI99606 HomoloGene55590 GeneCards: ABCA2 Gene
RNA expression pattern
PBB GE ABCA2 210100 s at tn.png
PBB GE ABCA2 212772 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 20 11305
Ensembl ENSG00000107331 ENSMUSG00000026944
UniProt Q9BZC7 A2AJ26
RefSeq (mRNA) NM_001606 NM_007379
RefSeq (protein) NP_001597 NP_031405
Location (UCSC) Chr 9:
139.9 – 139.92 Mb
Chr 2:
25.43 – 25.45 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family A member 2 is a protein that in humans is encoded by the ABCA2 gene.[1][2]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.[2]

See also[edit]

References[edit]

  1. ^ Luciani MF, Denizot F, Savary S, Mattei MG, Chimini G (Oct 1994). "Cloning of two novel ABC transporters mapping on human chromosome 9.". Genomics 21 (1): 150–9. doi:10.1006/geno.1994.1237. PMID 8088782. 
  2. ^ a b "Entrez Gene: ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.