This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies ( ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.
Piehler A, Kaminski WE, Wenzel JJ et al. (2002). "Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9.". Biochem. Biophys. Res. Commun.295 (2): 408–16. doi:10.1016/S0006-291X(02)00659-9. PMID12150964.
Allikmets R, Gerrard B, Hutchinson A, Dean M (1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum. Mol. Genet.5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID8894702.
Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res.6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID8889549.