ABCA9

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ATP-binding cassette, sub-family A (ABC1), member 9
Identifiers
Symbols ABCA9 ; EST640918
External IDs OMIM612507 MGI2386796 HomoloGene33332 GeneCards: ABCA9 Gene
Orthologs
Species Human Mouse
Entrez 10350 217262
Ensembl ENSG00000154258 ENSMUSG00000041797
UniProt Q8IUA7 Q8K449
RefSeq (mRNA) NM_080283 NM_147220
RefSeq (protein) NP_525022 NP_671753
Location (UCSC) Chr 17:
66.97 – 67.06 Mb
Chr 11:
110.1 – 110.17 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.[1]

Function[edit]

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies ( ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This gene is a member of the ABC1 subfamily and is clustered with four other ABC1 family members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.[1]

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