Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.
^Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum Mol Genet5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID8894702.
Hopper E, Belinsky MG, Zeng H et al. (2001). "Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily.". Cancer Lett.162 (2): 181–91. doi:10.1016/S0304-3835(00)00646-7. PMID11146224.
Chen ZS, Hopper-Borge E, Belinsky MG et al. (2003). "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).". Mol. Pharmacol.63 (2): 351–8. doi:10.1124/mol.63.2.351. PMID12527806.
Kao HH, Chang MS, Cheng JF, Huang JD (2003). "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7.". J. Biomed. Sci.10 (1): 98–110. doi:10.1159/000068078. PMID12566991.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Hopper-Borge E, Chen ZS, Shchaveleva I et al. (2004). "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel.". Cancer Res.64 (14): 4927–30. doi:10.1158/0008-5472.CAN-03-3111. PMID15256465.
Wooden SL, Kalb SR, Cotter RJ, Soloski MJ (2005). "Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis.". J. Immunol.175 (3): 1383–7. doi:10.4049/jimmunol.175.3.1383. PMID16034073.
Naramoto H, Uematsu T, Uchihashi T et al. (2007). "Multidrug resistance-associated protein 7 expression is involved in cross-resistance to docetaxel in salivary gland adenocarcinoma cell lines.". Int. J. Oncol.30 (2): 393–401. PMID17203221.