ABCC3

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ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Identifiers
Symbols ABCC3 ; ABC31; EST90757; MLP2; MOAT-D; MRP3; cMOAT2
External IDs OMIM604323 MGI1923658 HomoloGene68364 ChEMBL: 5918 GeneCards: ABCC3 Gene
RNA expression pattern
PBB GE ABCC3 208161 s at tn.png
PBB GE ABCC3 209641 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8714 76408
Ensembl ENSG00000108846 ENSMUSG00000020865
UniProt O15438 B2RX12
RefSeq (mRNA) NM_001144070 NM_029600
RefSeq (protein) NP_001137542 NP_083876
Location (UCSC) Chr 17:
48.71 – 48.77 Mb
Chr 11:
94.34 – 94.39 Mb
PubMed search [1] [2]

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.[1][2][3]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[3]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit|]]
Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 


See also[edit]

References[edit]

  1. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702. 
  2. ^ Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Dec 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J Natl Cancer Inst 90 (22): 1735–41. doi:10.1093/jnci/90.22.1735. PMID 9827529. 
  3. ^ a b "Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.