ABCC4

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ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Identifiers
Symbols ABCC4 ; EST170205; MOAT-B; MOATB; MRP4
External IDs OMIM605250 MGI2443111 HomoloGene74563 ChEMBL: 1743128 GeneCards: ABCC4 Gene
Orthologs
Species Human Mouse
Entrez 10257 239273
Ensembl ENSG00000125257 ENSMUSG00000032849
UniProt O15439 E9Q236
RefSeq (mRNA) NM_001105515 NM_001033336
RefSeq (protein) NP_001098985 NP_001028508
Location (UCSC) Chr 13:
95.67 – 95.95 Mb
Chr 14:
118.48 – 118.71 Mb
PubMed search [1] [2]

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.[1][2]

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.[3] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.[4]

MRP4/ABCC4 expression is dysregulated in several cancers [5][6][7] and is also upregulated in peritoneal endometriosis.[8]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

See also[edit]

References[edit]

  1. ^ "Entrez Gene: ATP-binding cassette". 
  2. ^ Lee K, Belinsky MG, Bell DW, Testa JR, Kruh GD (July 1998). "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter". Cancer Res. 58 (13): 2741–7. PMID 9661885. 
  3. ^ Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Cohen Aubart F, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompré AM, Hulot JS (August 2008). "Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation". J. Clin. Invest. 118 (8): 2747–57. doi:10.1172/JCI35067. PMC 2467383. PMID 18636120. 
  4. ^ Reid G, Wielinga P, Zelcer N,van der Heijden I, Kuil A, de Haas M, et al. The human multidrug resistanceprotein MRP4 functions as a prostaglandin efflux transporter and is inhibitedby nonsteroidal antiinflammatory drugs" Proc Natl Acad Sci U S A2003;100(16) 9244-9.
  5. ^ Ho LL, Kench JG, Handelsman DJ,Scheffer GL, Stricker PD, Grygiel JG, et al. Androgen regulation of multidrugresistance-associated protein 4 (MRP4/ABCC4) in prostate cancer" Prostate2008;68(13) 1421-9. 
  6. ^ Copsel S, Garcia C, Diez F,Vermeulem M, Baldi A, Bianciotti LG, et al. Multidrug resistance protein 4(MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cellproliferation and differentiation" J Biol Chem 2011;286(9) 6979-88. 
  7. ^ Holla VR, Backlund MG, Yang P,Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9. 
  8. ^ Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, CannyGO. Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)" Fertil Steril 2013 Jun;99(7) 1965-73.e2. doi:10.1016/j.fertnstert.2013.01.146

Further reading[edit]

External links[edit]