ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1
Identifiers
Symbols	ABCG1; ABC8; MGC34313; WHITE1
External IDs	OMIM: 603076 MGI: 107704 HomoloGene: 21022 GeneCards: ABCG1 Gene
Gene Ontology Molecular function • nucleotide binding • ATP binding • phospholipid binding • phospholipid transporter activity • cholesterol binding • ATPase activity • cholesterol transporter activity • toxin transporter activity • sterol-transporting ATPase activity • glycoprotein transporter activity • protein homodimerization activity • ADP binding • protein heterodimerization activity • protein dimerization activity Cellular component • Golgi membrane • intracellular • endosome • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus • plasma membrane • plasma membrane • integral to plasma membrane • external side of plasma membrane • recycling endosome Biological process • regulation of transcription, DNA-dependent • lipid metabolic process • transport • cholesterol metabolic process • detection of hormone stimulus • response to organic substance • negative regulation of macrophage derived foam cell differentiation • regulation of cholesterol esterification • positive regulation of cholesterol efflux • negative regulation of cholesterol storage • phospholipid transport • intracellular cholesterol transport • cholesterol efflux • phospholipid efflux • response to lipid • low-density lipoprotein particle remodeling • high-density lipoprotein particle remodeling • glycoprotein transport • lipoprotein metabolic process • cholesterol homeostasis • amyloid precursor protein catabolic process • reverse cholesterol transport • positive regulation of cholesterol biosynthetic process • phospholipid homeostasis • response to high density lipoprotein particle stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9619	11307
Ensembl	ENSG00000160179	ENSMUSG00000024030
UniProt	P45844	Q0VDW9
RefSeq (mRNA)	NM_004915.3	NM_009593.2
RefSeq (protein)	NP_004906.3	NP_033723.1
Location (UCSC)	Chr 21: 43.62 – 43.72 Mb	Chr 17: 31.19 – 31.25 Mb
PubMed search	[1]	[2]

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene. It is a homolog of the well-known Drosophila gene white.

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Several alternative splice variants have been identified.

See also

• ATP-binding cassette transporter

Further reading

• Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism". J. Lipid Res. 42 (10): 1513–20. PMID 11590207. 
• Andersson B, Wentland MA, Ricafrente JY et al (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Savary S, Denizot F, Luciani M et al (1996). "Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene". Mamm. Genome 7 (9): 673–6. doi:10.1007/s003359900203. PMID 8703120. 
• Croop JM, Tiller GE, Fletcher JA et al (1997). "Isolation and characterization of a mammalian homolog of the Drosophila white gene". Gene 185 (1): 77–85. doi:10.1016/S0378-1119(96)00633-6. PMID 9034316. 
• Yu W, Andersson B, Worley KC et al (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Klucken J, Büchler C, Orsó E et al (2000). "ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 817–22. doi:10.1073/pnas.97.2.817. PMC 15414. PMID 10639163. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15414. 
• Venkateswaran A, Repa JJ, Lobaccaro JM et al (2000). "Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols". J. Biol. Chem. 275 (19): 14700–7. doi:10.1074/jbc.275.19.14700. PMID 10799558. 
• Hattori M, Fujiyama A, Taylor TD et al (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
• Berry A, Scott HS, Kudoh J et al (2001). "Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region". Genomics 68 (1): 22–9. doi:10.1006/geno.2000.6253. PMID 10950923. 
• Langmann T, Porsch-Ozcürümez M, Unkelbach U et al (2000). "Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene". Biochim. Biophys. Acta 1494 (1–2): 175–80. PMID 11072082. 
• Lorkowski S, Rust S, Engel T et al (2001). "Genomic sequence and structure of the human ABCG1 (ABC8) gene". Biochem. Biophys. Res. Commun. 280 (1): 121–31. doi:10.1006/bbrc.2000.4089. PMID 11162488. 
• Porsch-Ozcurumez M, Langmann T, Heimerl S et al (2001). "The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux". J. Biol. Chem. 276 (15): 12427–33. doi:10.1074/jbc.M100218200. PMID 11279031. 
• Lorkowski S, Kratz M, Wenner C et al (2001). "Expression of the ATP-binding cassette transporter gene ABCG1 (ABC8) in Tangier disease". Biochem. Biophys. Res. Commun. 283 (4): 821–30. doi:10.1006/bbrc.2001.4863. PMID 11350058. 
• Kennedy MA, Venkateswaran A, Tarr PT et al (2001). "Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein". J. Biol. Chem. 276 (42): 39438–47. doi:10.1074/jbc.M105863200. PMID 11500512. 
• Kaplan R, Gan X, Menke JG et al (2003). "Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway". J. Lipid Res. 43 (6): 952–9. PMID 12032171. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Cserepes J, Szentpétery Z, Seres L et al (2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization". Biochem. Biophys. Res. Commun. 320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID 15240127. 

External links

• MeSH ABCG1+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.