ATP-binding cassette sub-family G member 4 is a protein that in humans is encoded by the ABCG4gene.
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined.
Engel T, Lorkowski S, Lueken A, et al. (2001). "The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages.". Biochem. Biophys. Res. Commun.288 (2): 483–8. doi:10.1006/bbrc.2001.5756. PMID11606068.
Annilo T, Tammur J, Hutchinson A, et al. (2002). "Human and mouse orthologs of a new ATP-binding cassette gene, ABCG4.". Cytogenet. Cell Genet.94 (3-4): 196–201. doi:10.1159/000048816. PMID11856881.
Yoshikawa M, Yabuuchi H, Kuroiwa A, et al. (2002). "Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4.". Gene293 (1-2): 67–75. doi:10.1016/S0378-1119(02)00719-9. PMID12137944.
Oldfield S, Lowry C, Ruddick J, Lightman S (2002). "ABCG4: a novel human white family ABC-transporter expressed in the brain and eye.". Biochim. Biophys. Acta1591 (1-3): 175–9. doi:10.1016/S0167-4889(02)00269-0. PMID12183068.
Cserepes J, Szentpétery Z, Seres L, et al. (2004). "Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization.". Biochem. Biophys. Res. Commun.320 (3): 860–7. doi:10.1016/j.bbrc.2004.06.037. PMID15240127.