|Abhydrolase domain containing 2|
|Symbols||; HS1-2; LABH2; PHPS1-2|
|RNA expression pattern|
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein.
Role in disease
The ABHD2 gene is down regulated in the lungs of people with Emphysema. Analysis of ABHD2 deficiency in mice found a decrease in phosphatidylcholine levels. The mice developed emphysema which was attributed to an increase in macrophage infiltration, increased inflammatory cytokine levels, an imbalance of protease/anti-protease, and an increase in cell death. This research suggests that ABHD2 is important in maintaining the structural integrity of the lungs, and that disruption of phospholipid metabolism in the alveoli may lead to the development of emphysema. Increased expression has also been seen in the lungs of smokers.
Up-regulation of ABDH2 has been observed in cells transfected with Hepatitis B virus (HBV) DNA (HepG2.2.15 cells). Expression was down-regulated by the drug lamivudine, used in the treatment of hepatitis B. It has been suggested that ABHD2 has an important role in HBV propagation and could be a potential drug target in the treatment of hepatitis B.
- "Entrez Gene: ABHD2 abhydrolase domain containing 2".
- Jin S, et al (March 2009). "Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene.". Biochem Biophys Res Commun. 380 (2): 419–24. doi:10.1016/j.bbrc.2009.01.098.
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- Miyata K, et al (Jan 2008). "Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.". Biochem Biophys Res Commun. 365 (2): 207–13. doi:10.1016/j.bbrc.2007.10.127. PMID 17980156.
- Ding X, Yang J and Wang S. (Mar–Apr 2011). "Antisense oligonucleotides targeting abhydrolase domain containing 2 block human hepatitis B virus propagation.". Oligonucleotides. 21 (2): 77–84. doi:10.1089/oli.2011.0280.
- Miyata K, Nakayama M, Mizuta S et al. (2007). "Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque". Biochem. Biophys. Res. Commun. 365 (2): 207–213. doi:10.1016/j.bbrc.2007.10.127. PMID 17980156.
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