From Wikipedia, the free encyclopedia
Jump to: navigation, search
Abl-interactor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ABI2 ; ABI-2; ABI2B; AIP-1; AblBP3; SSH3BP2; argBP1; argBPIA; argBPIB
External IDs OMIM606442 MGI106913 HomoloGene4209 GeneCards: ABI2 Gene
RNA expression pattern
PBB GE ABI2 211793 s at tn.png
PBB GE ABI2 207268 x at tn.png
PBB GE ABI2 209856 x at tn.png
More reference expression data
Species Human Mouse
Entrez 10152 329165
Ensembl ENSG00000138443 ENSMUSG00000026782
UniProt Q9NYB9 P62484
RefSeq (mRNA) NM_001282925 NM_001198570
RefSeq (protein) NP_001269854 NP_001185499
Location (UCSC) Chr 2:
204.19 – 204.31 Mb
Chr 1:
60.41 – 60.48 Mb
PubMed search [1] [2]

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[1][2][3]


ABI2 has been shown to interact with ABL1,[1][4]ADAM19,[5] and TRIM32.[6]


  1. ^ a b Dai Z, Pendergast AM (Dec 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236. 
  2. ^ Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (Sep 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520. 
  3. ^ "Entrez Gene: ABI2 abl interactor 2". 
  4. ^ Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093. 
  5. ^ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. 
  6. ^ Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609. 

Further reading[edit]

External links[edit]