ABI gene family member 3

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ABI family, member 3
Identifiers
Symbols ABI3 ; NESH; SSH3BP3
External IDs OMIM606363 MGI1913860 HomoloGene9505 GeneCards: ABI3 Gene
RNA expression pattern
PBB GE ABI3 gnf1h00229 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51225 66610
Ensembl ENSG00000108798 ENSMUSG00000018381
UniProt Q9P2A4 Q8BYZ1
RefSeq (mRNA) NM_001135186 NM_001163464
RefSeq (protein) NP_001128658 NP_001156936
Location (UCSC) Chr 17:
47.29 – 47.3 Mb
Chr 11:
95.83 – 95.84 Mb
PubMed search [1] [2]

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.[1][2][3]

Function[edit]

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.[3]

References[edit]

  1. ^ Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta 1493 (1-2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530. 
  2. ^ Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res 62 (8): 2215–9. PMID 11956071. 
  3. ^ a b "Entrez Gene: ABI3 ABI gene family, member 3". 

Further reading[edit]