ABLIM1

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Actin binding LIM protein 1
Identifiers
Symbols ABLIM1 ; ABLIM; LIMAB1; LIMATIN; abLIM-1
External IDs OMIM602330 MGI1194500 HomoloGene40994 GeneCards: ABLIM1 Gene
RNA expression pattern
PBB GE ABLIM1 200965 s at tn.png
PBB GE ABLIM1 210461 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3983 226251
Ensembl ENSG00000099204 ENSMUSG00000025085
UniProt O14639 Q8K4G5
RefSeq (mRNA) NM_001003407 NM_001103177
RefSeq (protein) NP_001003407 NP_001096647
Location (UCSC) Chr 10:
116.19 – 116.44 Mb
Chr 19:
57.03 – 57.31 Mb
PubMed search [1] [2]

Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene.[1][2]

Function[edit]

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

Interactions[edit]

ABLIM1 has been shown to interact with LDOC1.[3]

References[edit]

  1. ^ a b "Entrez Gene: ABLIM1 actin binding LIM protein 1". 
  2. ^ Roof DJ, Hayes A, Adamian M, Chishti AH, Li T (August 1997). "Molecular Characterization of abLIM, a Novel Actin-binding and Double Zinc Finger Protein". J. Cell Biol. 138 (3): 575–88. doi:10.1083/jcb.138.3.575. PMC 2141644. PMID 9245787. 
  3. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]