ABLIM3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Actin binding LIM protein family, member 3
Protein ABLIM3 PDB 1ujs.png
PDB rendering based on 1ujs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ABLIM3 ; HMFN1661
External IDs OMIM611305 MGI2442582 HomoloGene69175 GeneCards: ABLIM3 Gene
RNA expression pattern
PBB GE ABLIM3 205730 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22885 319713
Ensembl ENSG00000173210 ENSMUSG00000032735
UniProt O94929 Q69ZX8
RefSeq (mRNA) NM_014945 NM_001164491
RefSeq (protein) NP_055760 NP_001157963
Location (UCSC) Chr 5:
148.52 – 148.64 Mb
Chr 18:
61.8 – 61.91 Mb
PubMed search [1] [2]

The human ABLIM3 gene encodes the protein Actin-binding LIM protein 3.[1]

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.[2]

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling. An important paralog of this gene is LIMS1.


References[edit]

  1. ^ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3". 
  2. ^ Krupp M, Weinmann A, Galle PR, Teufel A. "Actin binding LIM protein 3 (abLIM3)." Int J Mol Med. 2006 Jan;17(1):129-33. PMID: 16328021

Further reading[edit]