ABLIM3

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Actin binding LIM protein family, member 3
Protein ABLIM3 PDB 1ujs.png
PDB rendering based on 1ujs.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ABLIM3 ; HMFN1661
External IDs OMIM611305 MGI2442582 HomoloGene69175 GeneCards: ABLIM3 Gene
RNA expression pattern
PBB GE ABLIM3 205730 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 22885 319713
Ensembl ENSG00000173210 ENSMUSG00000032735
UniProt O94929 Q69ZX8
RefSeq (mRNA) NM_001301015 NM_001164491
RefSeq (protein) NP_001287944 NP_001157963
Location (UCSC) Chr 5:
148.52 – 148.64 Mb
Chr 18:
61.8 – 61.91 Mb
PubMed search [1] [2]

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.[1]

Function[edit]

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.[2] An important paralog of this gene is LIMS1.

Clinical relevance[edit]

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

References[edit]

  1. ^ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3". 
  2. ^ Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine 17 (1). doi:10.3892/ijmm.17.1.129. PMID 16328021. 

Further reading[edit]