ABTB1

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Ankyrin repeat and BTB (POZ) domain containing 1
Identifiers
Symbols ABTB1 ; BPOZ; BTB3; BTBD21; EF1ABP
External IDs OMIM608308 MGI1933148 HomoloGene32731 GeneCards: ABTB1 Gene
Orthologs
Species Human Mouse
Entrez 80325 80283
Ensembl ENSG00000114626 ENSMUSG00000030083
UniProt Q969K4 Q99LJ2
RefSeq (mRNA) NM_032548 NM_030251
RefSeq (protein) NP_115937 NP_084527
Location (UCSC) Chr 3:
127.39 – 127.4 Mb
Chr 6:
88.84 – 88.84 Mb
PubMed search [1] [2]

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.[1][2][3]

Function[edit]

This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants encoding different isoforms.[3]

References[edit]

  1. ^ Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain". Biochem Biophys Res Commun 273 (3): 991–6. doi:10.1006/bbrc.2000.3053. PMID 10891360. 
  2. ^ Unoki M, Nakamura Y (Aug 2001). "Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway". Oncogene 20 (33): 4457–65. doi:10.1038/sj.onc.1204608. PMID 11494141. 
  3. ^ a b "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1". 

Further reading[edit]