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Acetyl-CoA acyltransferase 2
Symbols ACAA2 ; DSAEC
External IDs OMIM604770 MGI1098623 HomoloGene4456 GeneCards: ACAA2 Gene
EC number
Species Human Mouse
Entrez 10449 52538
Ensembl ENSG00000167315 ENSMUSG00000036880
UniProt P42765 Q8BWT1
RefSeq (mRNA) NM_006111 NM_177470
RefSeq (protein) NP_006102 NP_803421
Location (UCSC) Chr 18:
47.31 – 47.34 Mb
Chr 18:
74.78 – 74.81 Mb
PubMed search [1] [2]

3-Ketoacyl-CoA thiolase, mitochondrial also known as acetyl-Coenzyme A acyltransferase 2 is an enzyme that in humans is encoded by the ACAA2 gene.[1][2]

Acetyl-Coenzyme A acyltransferase 2 is an acetyl-CoA C-acyltransferase enzyme.


The encoded protein catalyzes the last step of the mitochondrial fatty acid beta oxidation spiral. Unlike most mitochondrial matrix proteins, it contains a non-cleavable amino-terminal targeting signal.[1]


  1. ^ a b "Entrez Gene: acetyl-Coenzyme A acyltransferase 2". 
  2. ^ Abe H, Ohtake A, Yamamoto S, Satoh Y, Takayanagi M, Amaya Y, Takiguchi M, Sakuraba H, Suzuki Y, Mori M (November 1993). "Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase". Biochim. Biophys. Acta 1216 (2): 304–6. doi:10.1016/0167-4781(93)90160-f. PMID 8241273. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.