Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene that is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB.
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase.
In a study done on rats, it was found that rats fed a fat-enriched diet whose ACAT2 gene were deleted were protected from dietary fat-induced atherosclerosis. LDL concentration, CE composition, and particle size were affected in ways that reduced atherogenesis in comparison to other rats whose ACAT2 gene were not modified.
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