ACCN2

Amiloride-sensitive cation channel 2, neuronal
Identifiers
Symbols	ACCN2; ASIC; ASIC1; ASIC1A; BNaC2; hBNaC2
External IDs	OMIM: 602866 MGI: 1194915 HomoloGene: 121755 GeneCards: ACCN2 Gene
Gene Ontology Molecular function • ion channel activity • protein binding • ligand-gated sodium channel activity Cellular component • plasma membrane • integral to plasma membrane Biological process • transport • ion transport • sodium ion transport • calcium ion transport • signal transduction • response to pH Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	41	11419
Ensembl	ENSG00000110881	ENSMUSG00000023017
UniProt	P78348	P97811
RefSeq (mRNA)	NM_001095.2	NM_009597.1
RefSeq (protein)	NP_001086.2	NP_033727.1
Location (UCSC)	Chr 12: 50.45 – 50.48 Mb	Chr 15: 99.5 – 99.53 Mb
PubMed search	[1]	[2]

Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.

Function

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.

Interactions

ACCN2 has been shown to interact with PICK1.

See also

• Acid-sensing ion channel

Further reading

• Corey DP, García-Añoveros J (1996). "Mechanosensation and the DEG/ENaC ion channels". Science 273 (5273): 323–4. doi:10.1126/science.273.5273.323. PMID 8685718. 
• Waldmann R, Champigny G, Bassilana F et al (1997). "A proton-gated cation channel involved in acid-sensing". Nature 386 (6621): 173–7. doi:10.1038/386173a0. PMID 9062189. 
• Bassilana F, Champigny G, Waldmann R et al (1997). "The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties". J. Biol. Chem. 272 (46): 28819–22. doi:10.1074/jbc.272.46.28819. PMID 9360943. 
• Bubien JK, Keeton DA, Fuller CM et al (1999). "Malignant human gliomas express an amiloride-sensitive Na+ conductance". Am. J. Physiol. 276 (6 Pt 1): C1405–10. PMID 10362604. 
• Askwith CC, Cheng C, Ikuma M et al (2000). "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels". Neuron 26 (1): 133–41. doi:10.1016/S0896-6273(00)81144-7. PMID 10798398. 
• Bässler EL, Ngo-Anh TJ, Geisler HS et al (2001). "Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b". J. Biol. Chem. 276 (36): 33782–7. doi:10.1074/jbc.M104030200. PMID 11448963. 
• Gunthorpe MJ, Smith GD, Davis JB, Randall AD (2001). "Characterisation of a human acid-sensing ion channel (hASIC1a) endogenously expressed in HEK293 cells". Pflugers Arch. 442 (5): 668–74. doi:10.1007/s004240100584. PMID 11512022. 
• Duggan A, Garcia-Anoveros J, Corey DP (2002). "The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons". J. Biol. Chem. 277 (7): 5203–8. doi:10.1074/jbc.M104748200. PMID 11739374. 
• Ji HL, Jovov B, Fu J et al (2002). "Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytes". J. Biol. Chem. 277 (10): 8395–405. doi:10.1074/jbc.M109465200. PMID 11748227. 
• Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222326. 
• Wemmie JA, Chen J, Askwith CC et al (2002). "The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory". Neuron 34 (3): 463–77. doi:10.1016/S0896-6273(02)00661-X. PMID 11988176. 
• Berdiev BK, Xia J, Jovov B et al (2003). "Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function". J. Biol. Chem. 277 (48): 45734–40. doi:10.1074/jbc.M208995200. PMID 12244121. 
• Ugawa S, Ueda T, Ishida Y et al (2002). "Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors". J. Clin. Invest. 110 (8): 1185–90. doi:10.1172/JCI15709. PMC 150796. PMID 12393854. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150796. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Leonard AS, Yermolaieva O, Hruska-Hageman A et al (2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149953. 
• Wemmie JA, Coryell MW, Askwith CC et al (2004). "Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3621–6. doi:10.1073/pnas.0308753101. PMC 373512. PMID 14988500. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=373512. 
• Poirot O, Vukicevic M, Boesch A, Kellenberger S (2004). "Selective regulation of acid-sensing ion channel 1 by serine proteases". J. Biol. Chem. 279 (37): 38448–57. doi:10.1074/jbc.M407381200. PMID 15247234. 
• Price MP, Thompson RJ, Eshcol JO et al (2005). "Stomatin modulates gating of acid-sensing ion channels". J. Biol. Chem. 279 (51): 53886–91. doi:10.1074/jbc.M407708200. PMID 15471860.