ACCN2

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Acid-sensing (proton-gated) ion channel 1
Identifiers
Symbols ASIC1 ; ACCN2; ASIC; BNaC2
External IDs OMIM602866 MGI1194915 HomoloGene121755 IUPHAR: ChEMBL: 1628477 GeneCards: ASIC1 Gene
RNA expression pattern
PBB GE ACCN2 37953 s at tn.png
PBB GE ACCN2 205156 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 41 11419
Ensembl ENSG00000110881 ENSMUSG00000023017
UniProt P78348 Q6NXK8
RefSeq (mRNA) NM_001095 NM_001289791
RefSeq (protein) NP_001086 NP_001276720
Location (UCSC) Chr 12:
50.45 – 50.48 Mb
Chr 15:
99.67 – 99.7 Mb
PubMed search [1] [2]

Amiloride-sensitive cation channel 2, neuronal is a protein that in humans is encoded by the ACCN2 gene.[1][2]

Function[edit]

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.[2]

Interactions[edit]

ACCN2 has been shown to interact with PICK1.[3][4]

See also[edit]

References[edit]

  1. ^ Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP (March 1997). "BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels". Proc Natl Acad Sci U S A 94 (4): 1459–64. doi:10.1073/pnas.94.4.1459. PMC 19813. PMID 9037075. 
  2. ^ a b "Entrez Gene: ACCN2 amiloride-sensitive cation channel 2, neuronal". 
  3. ^ Leonard, A Soren; Yermolaieva Olena, Hruska-Hageman Alesia, Askwith Candice C, Price Margaret P, Wemmie John A, Welsh Michael J (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 2029–34. doi:10.1073/pnas.252782799. ISSN 0027-8424. PMC 149953. PMID 12578970. 
  4. ^ Hruska-Hageman, Alesia M; Wemmie John A; Price Margaret P; Welsh Michael J (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. (England) 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. ISSN 0264-6021. PMC 1222326. PMID 11802773. 

Further reading[edit]