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Acid-sensing (proton-gated) ion channel family member 4
Symbols ASIC4 ; ACCN4; BNAC4
External IDs OMIM606715 MGI2652846 HomoloGene11166 GeneCards: ASIC4 Gene
Species Human Mouse
Entrez 55515 241118
Ensembl ENSG00000072182 ENSMUSG00000033007
UniProt Q96FT7 Q7TNS7
RefSeq (mRNA) NM_018674 NM_183022
RefSeq (protein) NP_878267 NP_898843
Location (UCSC) Chr 2:
220.38 – 220.4 Mb
Chr 1:
75.45 – 75.47 Mb
PubMed search [1] [2]

Amiloride-sensitive cation channel 4 also known as amiloride-sensitive cation channel 4, neuronal (ACCN4) or amiloride-sensitive cation channel 4, pituitary or acid-sensing ion channel 4 (ASIC4) is a membrane proteinthat in humans is encoded by the ACCN4 gene. The ASIC4 protein is a member of the acid-sensing ion channel family that is expressed in the pituitary gland and other parts of the brain. ASIC4 may have lost its ion transport function[1] but play a regulatory role through interactions with other members of the family[2] or other proteins.[3][4]


This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC.[4]


  1. ^ Ishikita, H. (2011). Wanunu, Meni, ed. "Proton-Binding Sites of Acid-Sensing Ion Channel 1". PLoS ONE 6 (2): e16920. doi:10.1371/journal.pone.0016920. PMC 3038902. PMID 21340031.  edit
  2. ^ Chen, X.; Polleichtner, G.; Kadurin, I.; Grunder, S. (2007). "Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H+". Journal of Biological Chemistry 282 (42): 30406–30413. doi:10.1074/jbc.M702229200. PMID 17686779.  edit
  3. ^ Donier, E.; Rugiero, F.; Jacob, C.; Wood, J. N. (2008). "Regulation of ASIC activity by ASIC4 new insights into ASIC channel function revealed by a yeast two-hybrid assay". European Journal of Neuroscience 28 (1): 74–86. doi:10.1111/j.1460-9568.2008.06282.x. PMID 18662336.  edit
  4. ^ a b "Entrez Gene: amiloride-sensitive cation channel 4". 

Further reading[edit]

  • Donier E, Rugiero F, Jacob C, Wood JN (2008). "Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assay.". Eur. J. Neurosci. 28 (1): 74–86. doi:10.1111/j.1460-9568.2008.06282.x. PMID 18662336. 
  • Gründer S, Geissler HS, Bässler EL, Ruppersberg JP (2000). "A new member of acid-sensing ion channels from pituitary gland.". Neuroreport 11 (8): 1607–11. doi:10.1097/00001756-200006050-00003. PMID 10852210. 
  • "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1998. doi:10.1101/gr.8.11.1097. PMID 9847074. 
  • Gründer S, Geisler HS, Rainier S, Fink JK (2001). "Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia.". Eur. J. Hum. Genet. 9 (9): 672–6. doi:10.1038/sj.ejhg.5200699. PMID 11571555. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.