ACOT11

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Acyl-CoA thioesterase 11
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACOT11 ; BFIT; STARD14; THEA; THEM1
External IDs OMIM606803 MGI1913736 HomoloGene11977 GeneCards: ACOT11 Gene
EC number 3.1.2.-
RNA expression pattern
PBB GE ACOT11 214763 at tn.png
PBB GE ACOT11 216103 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26027 329910
Ensembl ENSG00000162390 ENSMUSG00000034853
UniProt Q8WXI4 Q8VHQ9
RefSeq (mRNA) NM_015547 NM_025590
RefSeq (protein) NP_056362 NP_079866
Location (UCSC) Chr 1:
55.01 – 55.1 Mb
Chr 4:
106.74 – 106.8 Mb
PubMed search [1] [2]

Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene.[1][2][3][4]

This gene encodes a protein with acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates which relies on its StAR-related lipid transfer domain. Expression of a similar murine protein in brown adipose tissue is induced by cold exposure and repressed by warmth. Expression of the mouse protein has been associated with obesity, with higher expression found in obesity-resistant mice compared with obesity-prone mice. Alternative splicing results in two transcript variants encoding different isoforms.[4]

References[edit]

  1. ^ Adams SH, Chui C, Schilbach SL, Yu XX, Goddard AD, Grimaldi JC, Lee J, Dowd P, Colman S, Lewin DA (Nov 2001). "BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity". Biochem J 360 (Pt 1): 135–42. doi:10.1042/0264-6021:3600135. PMC 1222210. PMID 11696000. 
  2. ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133. 
  3. ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. 
  4. ^ a b "Entrez Gene: ACOT11 acyl-CoA thioesterase 11". 

Further reading[edit]