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Acyl-CoA thioesterase 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACOT2 ; CTE-IA; CTE1A; MTE1; PTE2; PTE2A; ZAP128
External IDs OMIM609972 MGI2159605 HomoloGene25661 GeneCards: ACOT2 Gene
EC number
RNA expression pattern
PBB GE ACOT2 202982 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10965 171210
Ensembl ENSG00000119673 ENSMUSG00000021226
UniProt P49753 Q9QYR9
RefSeq (mRNA) NM_006821 NM_134188
RefSeq (protein) NP_006812 NP_598949
Location (UCSC) Chr 14:
74.03 – 74.04 Mb
Chr 12:
83.99 – 83.99 Mb
PubMed search [1] [2]

Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.[1][2][3]

Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze Coenzyme A (CoA) esters, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA.[4]

ACOT2 shows high acyl-CoA thioesterase activity on medium- and long-chain acyl-CoAs, with an optimal pH of 8.5. It is most active on myristoyl-CoA but also shows high activity on palmitoyl-CoA, stearoyl-CoA, and arachidoyl-CoA.[2]


  1. ^ "Entrez Gene: ACOT2 acyl-CoA thioesterase 2". 
  2. ^ a b Jones JM, Gould SJ (August 2000). "Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase". Biochem. Biophys. Res. Commun. 275 (1): 233–40. doi:10.1006/bbrc.2000.3285. PMID 10944470. 
  3. ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (September 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. 
  4. ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (September 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J. Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133. 

Further reading[edit]