ACOT7

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Acyl-CoA thioesterase 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACOT7 ; ACH1; ACT; BACH; CTE-II; LACH; LACH1; hBACH
External IDs OMIM602587 MGI1917275 HomoloGene15780 GeneCards: ACOT7 Gene
EC number 3.1.2.2
RNA expression pattern
PBB GE ACOT7 208002 s at tn.png
PBB GE ACOT7 215728 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11332 70025
Ensembl ENSG00000097021 ENSMUSG00000028937
UniProt O00154 Q91V12
RefSeq (mRNA) NM_007274 NM_001146057
RefSeq (protein) NP_009205 NP_001139529
Location (UCSC) Chr 1:
6.32 – 6.45 Mb
Chr 4:
152.18 – 152.27 Mb
PubMed search [1] [2]

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.[1][2][3][4]

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.[4]

References[edit]

  1. ^ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051. 
  2. ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133. 
  3. ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. 
  4. ^ a b "Entrez Gene: ACOT7 acyl-CoA thioesterase 7". 

Further reading[edit]