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Acid phosphatase 2, lysosomal
Symbol ACP2
External IDs OMIM171650 MGI87882 HomoloGene1217 GeneCards: ACP2 Gene
EC number
RNA expression pattern
PBB GE ACP2 202767 at tn.png
More reference expression data
Species Human Mouse
Entrez 53 11432
Ensembl ENSG00000134575 ENSMUSG00000002103
UniProt P11117 P24638
RefSeq (mRNA) NM_001131064 NM_007387
RefSeq (protein) NP_001124536 NP_031413
Location (UCSC) Chr 11:
47.26 – 47.27 Mb
Chr 2:
91.2 – 91.21 Mb
PubMed search [1] [2]

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.[1][2]

Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.[2]


  1. ^ Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet 16 (1-5): 231–4. doi:10.1159/000130598. PMID 975882. 
  2. ^ a b "Entrez Gene: ACP2 acid phosphatase 2, lysosomal". 

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