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Acrosomal vesicle protein 1
Symbols ACRV1 ; D11S4365; SP-10; SPACA2
External IDs OMIM102525 MGI104590 HomoloGene1219 GeneCards: ACRV1 Gene
RNA expression pattern
PBB GE ACRV1 208013 s at tn.png
PBB GE ACRV1 206776 x at tn.png
PBB GE ACRV1 207969 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56 11451
Ensembl ENSG00000134940 ENSMUSG00000032110
UniProt P26436 P50289
RefSeq (mRNA) NM_001612 NM_007391
RefSeq (protein) NP_001603 NP_031417
Location (UCSC) Chr 11:
125.54 – 125.55 Mb
Chr 9:
36.69 – 36.7 Mb
PubMed search [1] [2]

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.[1][2][3]

This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.[3]


  1. ^ Wright RM, John E, Klotz K, Flickinger CJ, Herr JC (Jul 1990). "Cloning and sequencing of cDNAs coding for the human intra-acrosomal antigen SP-10". Biol Reprod 42 (4): 693–701. doi:10.1095/biolreprod42.4.693. PMID 1693291. 
  2. ^ Golden WL, von Kap-Herr C, Kurth B, Wright RM, Flickinger CJ, Eddy R, Shows T, Herr JC (Feb 1994). "Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23→q24 of chromosome 11 by nonisotopic in situ hybridization". Genomics 18 (2): 446–9. doi:10.1006/geno.1993.1496. PMID 8288254. 
  3. ^ a b "Entrez Gene: ACRV1 acrosomal vesicle protein 1". 

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