Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1gene.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.
In melanocytic cells ACSL1 gene expression may be regulated by MITF.
Abe T, Fujino T, Fukuyama R, et al. (1992). "Human long-chain acyl-CoA synthetase: structure and chromosomal location.". J. Biochem.111 (1): 123–8. PMID1607358.
Lageweg W, Wanders RJ, Tager JM (1991). "Long-chain-acyl-CoA synthetase and very-long-chain-acyl-CoA synthetase activities in peroxisomes and microsomes from rat liver. An enzymological study.". Eur. J. Biochem.196 (2): 519–23. doi:10.1111/j.1432-1033.1991.tb15844.x. PMID2007410.
Cantú ES, Sprinkle TJ, Ghosh B, Singh I (1996). "The human palmitoyl-CoA ligase (FACL2) gene maps to the chromosome 4q34-q35 region by fluorescence in situ hybridization (FISH) and somatic cell hybrid panels.". Genomics28 (3): 600–2. doi:10.1006/geno.1995.1199. PMID7490105.
Wu P, Bremer J (1994). "Activation of alkylthioacrylic acids in subcellular fractions of rat tissues: a new spectrophotometric method for assay of acyl-CoA synthetase.". Biochim. Biophys. Acta1215 (1–2): 87–92. doi:10.1016/0005-2760(94)90095-7. PMID7948012.
Singh I, Lazo O, Kremser K (1993). "Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain". Biochim. Biophys. Acta1170 (1): 44–52. doi:10.1016/0005-2760(93)90174-8. PMID8399326.
Ghosh B, Barbosa E, Singh I (1996). "Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression". Mol. Cell. Biochem.151 (1): 77–81. doi:10.1007/BF01076899. PMID8584017.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res.6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID8889548.