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Acyl-CoA synthetase long-chain family member 1
External IDs OMIM152425 MGI102797 HomoloGene37561 GeneCards: ACSL1 Gene
EC number
RNA expression pattern
PBB GE ACSL1 201963 at tn.png
PBB GE ACSL1 207275 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2180 14081
Ensembl ENSG00000151726 ENSMUSG00000018796
UniProt P33121 P41216
RefSeq (mRNA) NM_001286708 NM_007981
RefSeq (protein) NP_001273637 NP_032007
Location (UCSC) Chr 4:
185.68 – 185.75 Mb
Chr 8:
46.47 – 46.54 Mb
PubMed search [1] [2]

Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene.[1][2][3]

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation.[3]

In melanocytic cells ACSL1 gene expression may be regulated by MITF.[4]


  1. ^ Suzuki H, Kawarabayasi Y, Kondo J, Abe T, Nishikawa K, Kimura S, Hashimoto T, Yamamoto T (Jun 1990). "Structure and regulation of rat long-chain acyl-CoA synthetase". J Biol Chem 265 (15): 8681–5. PMID 2341402. 
  2. ^ Stanczak H, Stanczak JJ, Singh I (Feb 1992). "Chromosomal localization of the human gene for palmitoyl-CoA ligase (FACL1)". Cytogenet Cell Genet 59 (1): 17–9. doi:10.1159/000133189. PMID 1531127. 
  3. ^ a b "Entrez Gene: ACSL1 acyl-CoA synthetase long-chain family member 1". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

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