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Acyl-CoA synthetase long-chain family member 3
Symbols ACSL3 ; ACS3; FACL3; PRO2194
External IDs OMIM602371 MGI1921455 HomoloGene3278 GeneCards: ACSL3 Gene
EC number
RNA expression pattern
PBB GE ACSL3 201661 s at tn.png
PBB GE ACSL3 201660 at tn.png
PBB GE ACSL3 201662 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2181 74205
Ensembl ENSG00000123983 ENSMUSG00000032883
UniProt O95573 Q9CZW4
RefSeq (mRNA) NM_004457 NM_001033606
RefSeq (protein) NP_004448 NP_001028778
Location (UCSC) Chr 2:
223.73 – 223.81 Mb
Chr 1:
78.66 – 78.71 Mb
PubMed search [1] [2]

Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.[1]


The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.[1]


Further reading[edit]