ACTL6A

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Actin-like 6A
Identifiers
Symbols ACTL6A ; ACTL6; ARPN-BETA; Arp4; BAF53A; INO80K
External IDs OMIM604958 MGI1861453 HomoloGene55811 GeneCards: ACTL6A Gene
RNA expression pattern
PBB GE ACTL6A 202666 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 86 56456
Ensembl ENSG00000136518 ENSMUSG00000027671
UniProt O96019 Q9Z2N8
RefSeq (mRNA) NM_004301 NM_019673
RefSeq (protein) NP_004292 NP_062647
Location (UCSC) Chr 3:
179.28 – 179.31 Mb
Chr 3:
32.71 – 32.73 Mb
PubMed search [1] [2]

Actin-like protein 6A is a protein that in humans is encoded by the ACTL6A gene.[1][2][3]

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.[3]

Interactions[edit]

ACTL6A has been shown to interact with SMARCA2,[4][5][6] Myc,[5] Transformation/transcription domain-associated protein,[5] RuvB-like 1[5] and SMARCA4.[1][4]

References[edit]

  1. ^ a b Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR (December 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. PMID 9845365. 
  2. ^ Harata M, Mochizuki R, Mizuno S (July 1999). "Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues". Biosci Biotechnol Biochem 63 (5): 917–23. doi:10.1271/bbb.63.917. PMID 10380635. 
  3. ^ a b "Entrez Gene: ACTL6A actin-like 6A". 
  4. ^ a b Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. (ENGLAND) 15 (19): 5370–82. ISSN 0261-4189. PMC 452280. PMID 8895581. 
  5. ^ a b c d Park, Jeonghyeon; Wood Marcelo A; Cole Michael D (March 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Mol. Cell. Biol. (United States) 22 (5): 1307–16. doi:10.1128/MCB.22.5.1307-1316.2002. ISSN 0270-7306. PMC 134713. PMID 11839798. 
  6. ^ Kuroda, Yukiko; Oma Yukako; Nishimori Katsuhiko; Ohta Tsutomu; Harata Masahiko (November 2002). "Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex". Biochem. Biophys. Res. Commun. (United States) 299 (2): 328–34. doi:10.1016/S0006-291X(02)02637-2. ISSN 0006-291X. PMID 12437990. 

Further reading[edit]