ACTL6B

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Actin-like 6B
Identifiers
Symbols ACTL6B ; ACTL6; BAF53B
External IDs OMIM612458 MGI1933548 HomoloGene81844 GeneCards: ACTL6B Gene
RNA expression pattern
PBB GE ACTL6B 206013 s at tn.png
PBB GE ACTL6B 206014 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51412 83766
Ensembl ENSG00000077080 ENSMUSG00000029712
UniProt O94805 Q99MR0
RefSeq (mRNA) NM_016188 NM_031404
RefSeq (protein) NP_057272 NP_113581
Location (UCSC) Chr 7:
100.24 – 100.25 Mb
Chr 5:
137.55 – 137.57 Mb
PubMed search [1] [2]

Actin-like protein 6B is a protein that in humans is encoded by the ACTL6B gene.[1][2]

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.[2]

Interactions[edit]

ACTL6B has been shown to interact with CTBP1.[3]

References[edit]

  1. ^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (December 1998). "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes". Genome Res 8 (10): 1060–73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793. 
  2. ^ a b "Entrez Gene: ACTL6B actin-like 6B". 
  3. ^ Oma, Yukako; Nishimori Katsuhiko; Harata Masahiko (February 2003). "The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP". Biochem. Biophys. Res. Commun. (United States) 301 (2): 521–528. doi:10.1016/S0006-291X(02)03073-5. ISSN 0006-291X. PMID 12565893. 

Further reading[edit]