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ARP3 actin-related protein 3 homolog (yeast)
Protein ACTR3 PDB 1k8k.png
PDB rendering based on 1k8k.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACTR3 ; ARP3
External IDs OMIM604222 MGI1921367 HomoloGene68483 GeneCards: ACTR3 Gene
RNA expression pattern
PBB GE ACTR3 200996 at tn.png
PBB GE ACTR3 213101 s at tn.png
PBB GE ACTR3 213102 at tn.png
More reference expression data
Species Human Mouse
Entrez 10096 74117
Ensembl ENSG00000115091 ENSMUSG00000026341
UniProt P61158 Q99JY9
RefSeq (mRNA) NM_001277140 NM_001205385
RefSeq (protein) NP_001264069 NP_001192314
Location (UCSC) Chr 2:
114.65 – 114.72 Mb
Chr 1:
125.39 – 125.44 Mb
PubMed search [1] [2]

Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene.[1]

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.[2]


ACTR3 has been shown to interact with Cortactin.[3][4]


  1. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (August 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079. 
  2. ^ "Entrez Gene: ACTR3 ARP3 actin-related protein 3 homolog (yeast)". 
  3. ^ Weed, S A; Karginov A V; Schafer D A; Weaver A M; Kinley A W; Cooper J A; Parsons J T (October 2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". J. Cell Biol. (UNITED STATES) 151 (1): 29–40. doi:10.1083/jcb.151.1.29. ISSN 0021-9525. PMC 2189811. PMID 11018051. 
  4. ^ Di Ciano, Caterina; Nie Zilin; Szászi Katalin; Lewis Alison; Uruno Takehito; Zhan Xi; Rotstein Ori D; Mak Alan; Kapus András (September 2002). "Osmotic stress-induced remodeling of the cortical cytoskeleton". Am. J. Physiol., Cell Physiol. (United States) 283 (3): C850–65. doi:10.1152/ajpcell.00018.2002. ISSN 0363-6143. PMID 12176742. 

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