ACVR1C

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Activin A receptor, type IC
Identifiers
Symbols ACVR1C ; ACVRLK7; ALK7
External IDs OMIM608981 MGI2661081 HomoloGene26724 ChEMBL: 5642 GeneCards: ACVR1C Gene
EC number 2.7.11.30
Orthologs
Species Human Mouse
Entrez 130399 269275
Ensembl ENSG00000123612 ENSMUSG00000026834
UniProt Q8NER5 Q8K348
RefSeq (mRNA) NM_001111031 NM_001033369
RefSeq (protein) NP_001104501 NP_001028541
Location (UCSC) Chr 2:
158.39 – 158.49 Mb
Chr 2:
58.27 – 58.36 Mb
PubMed search [1] [2]

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene.[1] ACVR1C is a type I receptor for the TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.[1]

ACVR1C transduces signals of Nodal. Nodal binds to ACVR2B and then forms a complex with ACR1C. These go on to recruit the R-SMADs SMAD2 or SMAD3.[2]

References[edit]

  1. ^ a b Bondestam J, Huotari MA, Morén A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O (2001). "cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)". Cytogenet. Cell Genet. 95 (3–4): 157–62. doi:10.1159/000059339. PMID 12063393. 
  2. ^ Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS (July 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol. Pharmacol. 62 (1): 65–74. doi:10.1124/mol.62.1.65. PMID 12065756. 


Further reading[edit]