ACVR2B

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Activin A receptor, type IIB
Protein ACVR2B PDB 1nys.png
PDB rendering based on 1nys.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ACVR2B ; ACTRIIB; ActR-IIB; HTX4
External IDs OMIM602730 MGI87912 HomoloGene863 ChEMBL: 5466 GeneCards: ACVR2B Gene
EC number 2.7.11.30
RNA expression pattern
PBB GE ACVR2B 220028 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 93 11481
Ensembl ENSG00000114739 ENSMUSG00000061393
UniProt Q13705 P27040
RefSeq (mRNA) NM_001106 NM_007397
RefSeq (protein) NP_001097 NP_031423
Location (UCSC) Chr 3:
38.5 – 38.53 Mb
Chr 9:
119.4 – 119.43 Mb
PubMed search [1] [2]

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.[1][2][3] ACVR2B is an activin type 2 receptor.

Function[edit]

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.[3]

Interactions[edit]

ACVR2B has been shown to interact with ACVR1B[4][5] and SYNJ2BP.[6]

References[edit]

  1. ^ Hilden K, Tuuri T, Eramaa M, Ritvos O (May 1994). "Expression of type II activin receptor genes during differentiation of human K562 cells and cDNA cloning of the human type IIB activin receptor". Blood 83 (8): 2163–70. PMID 8161782. 
  2. ^ Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, Ogawa M, Nakamura Y (July 1998). "Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene". J Hum Genet 43 (2): 132–4. doi:10.1007/s100380050054. PMID 9621519. 
  3. ^ a b "Entrez Gene: ACVR2B activin A receptor, type IIB". 
  4. ^ Attisano L, Wrana JL, Montalvo E, Massagué J (March 1996). "Activation of signalling by the activin receptor complex". Mol. Cell. Biol. 16 (3): 1066–73. PMC 231089. PMID 8622651. 
  5. ^ De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. doi:10.1006/excr.1996.0142. PMID 8612709. 
  6. ^ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656. 

Further reading[edit]