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Aminoacylase 1
Protein ACY1 PDB 1q7l.png
PDB rendering based on 1q7l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACY1 ; ACY-1; ACY1D; HEL-S-5
External IDs OMIM104620 MGI87913 HomoloGene110440 GeneCards: ACY1 Gene
EC number
RNA expression pattern
PBB GE ACY1 202740 at tn.png
More reference expression data
Species Human Mouse
Entrez 95 109652
Ensembl ENSG00000114786 ENSMUSG00000023262
UniProt Q03154 Q99JW2
RefSeq (mRNA) NM_000666 NM_001276442
RefSeq (protein) NP_000657 NP_001263371
Location (UCSC) Chr 3:
52.01 – 52.02 Mb
Chr 9:
106.43 – 106.44 Mb
PubMed search [1] [2]

Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.[1][2][3]

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.[3]


  1. ^ Miller YE, Drabkin H, Jones C, Fisher JH (May 1991). "Human aminoacylase-1: cloning, regional assignment to distal chromosome 3p21.1, and identification of a cross-hybridizing sequence on chromosome 18". Genomics 8 (1): 149–154. doi:10.1016/0888-7543(90)90237-O. PMID 1707030. 
  2. ^ Voss R, Lerer I, Povey S, Solomon E, Bobrow M (Mar 1982). "Confirmation and further regional assignment of aminoacylase 1 (acy-1) on human chromosome 3 using a simplified detection method". Ann Hum Genet 44 (Pt 1): 1–9. doi:10.1111/j.1469-1809.1980.tb00940.x. PMID 6948533. 
  3. ^ a b "Entrez Gene: ACY1 aminoacylase 1". 

Further reading[edit]