From Wikipedia, the free encyclopedia
Jump to: navigation, search
Acylphosphatase 2, muscle type
Protein ACYP2 PDB 1aps.png
PDB rendering based on 1aps.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ACYP2 ; ACYM; ACYP
External IDs OMIM102595 MGI1922822 HomoloGene41776 GeneCards: ACYP2 Gene
EC number
RNA expression pattern
PBB GE ACYP2 gnf1h09944 at tn.png
More reference expression data
Species Human Mouse
Entrez 98 75572
Ensembl ENSG00000170634 ENSMUSG00000060923
UniProt P14621 P56375
RefSeq (mRNA) NM_138448 NM_029344
RefSeq (protein) NP_612457 NP_083620
Location (UCSC) Chr 2:
54.2 – 54.53 Mb
Chr 11:
30.51 – 30.65 Mb
PubMed search [1] [2]

Acylphosphatase-2 is an enzyme that in humans is encoded by the ACYP2 gene.[1][2]

Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation.[2]


  1. ^ Modesti A, Raugei G, Taddei N, Marzocchini R, Vecchi M, Camici G, Manao G, Ramponi G (Feb 1994). "Chemical synthesis and expression of a gene coding for human muscle acylphosphatase". Biochim Biophys Acta 1216 (3): 369–74. doi:10.1016/0167-4781(93)90003-v. PMID 8268218. 
  2. ^ a b "Entrez Gene: ACYP2 acylphosphatase 2, muscle type". 

Further reading[edit]