AD-mix

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AD-mix in organic chemistry is a commercially available mixture of reagents for performing amongst others the Sharpless asymmetric dihydroxylation of alkenes. The two letters AD, stand for asymmetric dihydroxylation. The mix is available in two variations, "AD-mix α" and "AD-mix β" following ingredient lists published by Sharpless.[1] As such it is used in research laboratories.

The mixes contain:

DHQ2PHAL AD-mix
In AD-mix α (DHQ)2PHAL (top) is the phthalazine adduct with dihydroquinine.
DHQD2PHAL AD-mix
In AD-mix β; (DHQD)2PHAL is the phthalazine adduct with dihydroquinidine.

See also[edit]

References[edit]

  1. ^ ^ Sharpless, K. B., et al. J. Org. Chem. 1992, 57, 2768-2771. (doi:10.1021/jo00036a003)

External links[edit]

  • Catalytic Asymmetric Dihydroxylation of Alkenes at Imperial College London Link