ADAM11

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ADAM metallopeptidase domain 11
Identifiers
Symbols ADAM11 ; MDC
External IDs OMIM155120 MGI1098667 HomoloGene7614 GeneCards: ADAM11 Gene
RNA expression pattern
PBB GE ADAM11 207880 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4185 11488
Ensembl ENSG00000073670 ENSMUSG00000020926
UniProt O75078 Q9R1V4
RefSeq (mRNA) NM_002390 NM_001110778
RefSeq (protein) NP_002381 NP_001104248
Location (UCSC) Chr 17:
42.84 – 42.86 Mb
Chr 11:
102.76 – 102.78 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.[2]

References[edit]

  1. ^ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040. 
  2. ^ a b "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.976