From Wikipedia, the free encyclopedia
Jump to: navigation, search
ADAM metallopeptidase domain 18
Symbols ADAM18 ; ADAM27; tMDCIII
External IDs MGI105986 HomoloGene74941 GeneCards: ADAM18 Gene
RNA expression pattern
PBB GE ADAM18 207597 at tn.png
More reference expression data
Species Human Mouse
Entrez 8749 13524
Ensembl ENSG00000168619 ENSMUSG00000031552
UniProt Q9Y3Q7 Q9R157
RefSeq (mRNA) NM_001190956 NM_010084
RefSeq (protein) NP_001177885 NP_034214
Location (UCSC) Chr 8:
39.44 – 39.59 Mb
Chr 8:
24.6 – 24.67 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[2]


  1. ^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459. 
  2. ^ a b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.957