ADAM18

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ADAM metallopeptidase domain 18
Identifiers
Symbols ADAM18 ; ADAM27; tMDCIII
External IDs MGI105986 HomoloGene74941 GeneCards: ADAM18 Gene
RNA expression pattern
PBB GE ADAM18 207597 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8749 13524
Ensembl ENSG00000168619 ENSMUSG00000031552
UniProt Q9Y3Q7 Q9R157
RefSeq (mRNA) NM_001190956 NM_010084
RefSeq (protein) NP_001177885 NP_034214
Location (UCSC) Chr 8:
39.44 – 39.59 Mb
Chr 8:
24.6 – 24.67 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 18 is an enzyme that in humans is encoded by the ADAM18 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein.[2]

References[edit]

  1. ^ Frayne J, Hurd EA, Hall L (Aug 2002). "Human tMDC III: a sperm protein with a potential role in oocyte recognition". Mol Hum Reprod 8 (9): 817–22. doi:10.1093/molehr/8.9.817. PMID 12200459. 
  2. ^ a b "Entrez Gene: ADAM18 ADAM metallopeptidase domain 18". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.957