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ADAM metallopeptidase domain 19
External IDs OMIM603640 MGI105377 HomoloGene74925 GeneCards: ADAM19 Gene
RNA expression pattern
PBB GE ADAM19 209765 at tn.png
More reference expression data
Species Human Mouse
Entrez 8728 11492
Ensembl ENSG00000135074 ENSMUSG00000011256
UniProt Q9H013 O35674
RefSeq (mRNA) NM_023038 NM_001291890
RefSeq (protein) NP_150377 NP_001278819
Location (UCSC) Chr 5:
156.82 – 157 Mb
Chr 11:
46.06 – 46.15 Mb
PubMed search [1] [2]

ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.[1]


This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.[1]


ADAM19 has been shown to interact with ABI2.[2]


  1. ^ a b "Entrez Gene: ADAM19 ADAM metallopeptidase domain 19 (meltrin beta)". 
  2. ^ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. 

Further reading[edit]