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ADAM metallopeptidase domain 2
Symbols ADAM2 ; CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30; PH30-beta
External IDs OMIM601533 MGI1340894 HomoloGene1127 IUPHAR: 1651 GeneCards: ADAM2 Gene
RNA expression pattern
PBB GE ADAM2 207664 at tn.png
More reference expression data
Species Human Mouse
Entrez 2515 11495
Ensembl ENSG00000104755 ENSMUSG00000022039
UniProt Q99965 Q60718
RefSeq (mRNA) NM_001278113 NM_009618
RefSeq (protein) NP_001265042 NP_033748
Location (UCSC) Chr 8:
39.6 – 39.7 Mb
Chr 14:
66.03 – 66.08 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 2 is an enzyme that in humans is encoded by the ADAM2 gene.[1][2][3]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[3]


  1. ^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (Aug 1996). "Molecular cloning of the human fertilin beta subunit". Biochem Biophys Res Commun 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389. 
  2. ^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (Jun 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941. 
  3. ^ a b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.950