ADAM2

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ADAM metallopeptidase domain 2
Identifiers
Symbols ADAM2 ; CRYN1; CRYN2; CT15; FTNB; PH-30b; PH30; PH30-beta
External IDs OMIM601533 MGI1340894 HomoloGene1127 GeneCards: ADAM2 Gene
RNA expression pattern
PBB GE ADAM2 207664 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2515 11495
Ensembl ENSG00000104755 ENSMUSG00000022039
UniProt Q99965 Q60718
RefSeq (mRNA) NM_001278113 NM_009618
RefSeq (protein) NP_001265042 NP_033748
Location (UCSC) Chr 8:
39.6 – 39.7 Mb
Chr 14:
66.03 – 66.08 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 2 is an enzyme that in humans is encoded by the ADAM2 gene.[1][2][3]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[3]

References[edit]

  1. ^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (Aug 1996). "Molecular cloning of the human fertilin beta subunit". Biochem Biophys Res Commun 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389. 
  2. ^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (Jun 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941. 
  3. ^ a b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.950