ADAM33

ADAM metallopeptidase domain 33
PDB rendering based on 1r54.
Available structures PDB 1R54, 1R55
Identifiers
Symbols	ADAM33; C20orf153; DJ964F7.1; DKFZp434K0521; FLJ35308; FLJ36751; MGC149823; MGC71889
External IDs	OMIM: 607114 MGI: 1341813 HomoloGene: 11881 GeneCards: ADAM33 Gene
Gene Ontology Molecular function • metalloendopeptidase activity • peptidase activity • zinc ion binding • metal ion binding Cellular component • membrane • integral to membrane Biological process • proteolysis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80332	110751
Ensembl	ENSG00000149451	ENSMUSG00000027318
UniProt	Q9BZ11	Q6TYY9
RefSeq (mRNA)	NM_025220.2	NM_033615
RefSeq (protein)	NP_079496.1	NP_291093
Location (UCSC)	Chr 20: 3.65 – 3.66 Mb	Chr 2: 130.88 – 130.89 Mb
PubMed search	[1]	[2]

Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Further reading

• Holgate ST, Davies DE, Rorke S et al (2005). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical reviews in allergy & immunology 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID 15347848. 
• Holloway JW, Davies DE, Powell R et al (2007). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert reviews in molecular medicine 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895. 
• Holgate ST, Yang Y, Haitchi HM et al (2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society 3 (5): 440–3. doi:10.1513/pats.200603-026AW. PMID 16799089. 
• Deloukas P, Matthews LH, Ashurst J et al (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Van Eerdewegh P, Little RD, Dupuis J et al (2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature 418 (6896): 426–30. doi:10.1038/nature00878. PMID 12110844. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Garlisi CG, Zou J, Devito KE et al (2003). "Human ADAM33: protein maturation and localization". Biochem. Biophys. Res. Commun. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID 12535637. 
• Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". J. Hum. Genet. 48 (5): 278–81. doi:10.1007/s10038-003-0019-1. PMID 12768445. 
• Clark HF, Gurney AL, Abaya E et al (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Howard TD, Postma DS, Jongepier H et al (2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". J. Allergy Clin. Immunol. 112 (4): 717–22. doi:10.1016/S0091. PMID 14564349. 
• Orth P, Reichert P, Wang W et al (2004). "Crystal structure of the catalytic domain of human ADAM33". J. Mol. Biol. 335 (1): 129–37. doi:10.1016/j.jmb.2003.10.037. PMID 14659745. 
• Zou J, Zhu F, Liu J et al (2004). "Catalytic activity of human ADAM33". J. Biol. Chem. 279 (11): 9818–30. doi:10.1074/jbc.M309696200. PMID 14676211. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Powell RM, Wicks J, Holloway JW et al (2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". Am. J. Respir. Cell Mol. Biol. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294. 
• Haitchi HM, Powell RM, Shaw TJ et al (2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". Am. J. Respir. Crit. Care Med. 171 (9): 958–65. doi:10.1164/rccm.200409-1251OC. PMID 15709049. 
• Zou J, Zhang R, Zhu F et al (2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry 44 (11): 4247–56. doi:10.1021/bi0476230. PMID 15766253. 
• Simpson A, Maniatis N, Jury F et al (2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". Am. J. Respir. Crit. Care Med. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180. 

External links

• The MEROPS online database for peptidases and their inhibitors: M12.244