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ADAM metallopeptidase domain 8
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ADAM8 ; CD156; CD156a; MS2
External IDs OMIM602267 MGI107825 HomoloGene74384 GeneCards: ADAM8 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE ADAM8 205180 s at tn.png
PBB GE ADAM8 205179 s at tn.png
More reference expression data
Species Human Mouse
Entrez 101 11501
Ensembl ENSG00000151651 ENSMUSG00000025473
UniProt P78325 Q05910
RefSeq (mRNA) NM_001109 NM_001291066
RefSeq (protein) NP_001100 NP_001277995
Location (UCSC) Chr 10:
133.26 – 133.28 Mb
Chr 7:
139.98 – 139.99 Mb
PubMed search [1] [2]

A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene.[1][2]

This gene encodes a member of the ADAM (a disintegrin and metalloproteinase domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.[2]

See also[edit]


  1. ^ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (May 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482. 
  2. ^ a b "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.