A Disintegrin and metalloproteinase domain-containing protein 8 is an enzyme that in humans is encoded by the ADAM8gene.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration.
Schlomann U, Rathke-Hartlieb S, Yamamoto S et al. (2001). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration". J. Neurosci.20 (21): 7964–71. PMID11050116.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res.16 (1): 55–65. doi:10.1101/gr.4039406. PMC1356129. PMID16344560.
Foley SC, Mogas AK, Olivenstein R et al. (2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma". J. Allergy Clin. Immunol.119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID17339047.
Gómez-Gaviro M, Domínguez-Luis M, Canchado J et al. (2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". J. Immunol.178 (12): 8053–63. PMID17548643.
Valkovskaya N, Kayed H, Felix K et al. (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer". J. Cell. Mol. Med.11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMID17979891.