ADAM9

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ADAM metallopeptidase domain 9
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ADAM9 ; CORD9; MCMP; MDC9; Mltng
External IDs OMIM602713 MGI105376 HomoloGene20824 ChEMBL: 5982 GeneCards: ADAM9 Gene
Orthologs
Species Human Mouse
Entrez 8754 11502
Ensembl ENSG00000168615 ENSMUSG00000031555
UniProt Q13443 Q61072
RefSeq (mRNA) NM_001005845 NM_001270996
RefSeq (protein) NP_003807 NP_001257925
Location (UCSC) Chr 8:
38.85 – 38.96 Mb
Chr 8:
24.95 – 25.02 Mb
PubMed search [1] [2]

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.[1][2]

Function[edit]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.[2]

Interactions[edit]

ADAM9 has been shown to interact with:


References[edit]

  1. ^ Weskamp G, Kratzschmar J, Reid MS, Blobel CP (Jul 1996). "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains". J Cell Biol 132 (4): 717–26. doi:10.1083/jcb.132.4.717. PMC 2199860. PMID 8647900. 
  2. ^ a b "Entrez Gene: ADAM9 ADAM metallopeptidase domain 9 (meltrin gamma)". 
  3. ^ Nelson KK, Schlöndorff J, Blobel CP (Nov 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 Pt 3: 673–80. doi:10.1042/0264-6021:3430673. PMC 1220601. PMID 10527948. 
  4. ^ a b Howard L, Nelson KK, Maciewicz RA, Blobel CP (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379. 

Further reading[edit]

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