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ADAM metallopeptidase with thrombospondin type 1 motif, 10
Symbols ADAMTS10 ; ADAM-TS10; ADAMTS-10; WMS; WMS1
External IDs OMIM608990 MGI2449112 HomoloGene81940 GeneCards: ADAMTS10 Gene
RNA expression pattern
PBB GE ADAMTS10 gnf1h03448 at tn.png
PBB GE ADAMTS10 gnf1h03449 s at tn.png
PBB GE ADAMTS10 gnf1h03450 at tn.png
More reference expression data
Species Human Mouse
Entrez 81794 224697
Ensembl ENSG00000142303 ENSMUSG00000024299
UniProt Q9H324 P58459
RefSeq (mRNA) NM_001282352 NM_172619
RefSeq (protein) NP_001269281 NP_766207
Location (UCSC) Chr 19:
8.65 – 8.68 Mb
Chr 17:
33.52 – 33.55 Mb
PubMed search [1] [2]

A disintegrin and metalloproteinase with thrombospondin motifs 10 is an enzyme that in humans is encoded by the ADAMTS10 gene.[1]

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[1]


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