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ADAM metallopeptidase with thrombospondin type 1 motif, 3
Symbols ADAMTS3 ; ADAMTS-4
External IDs OMIM605011 MGI3045353 HomoloGene8596 IUPHAR: 1676 GeneCards: ADAMTS3 Gene
EC number 3.4.24.-
RNA expression pattern
PBB GE ADAMTS3 214913 at tn.png
More reference expression data
Species Human Mouse
Entrez 9508 330119
Ensembl ENSG00000156140 ENSMUSG00000043635
UniProt O15072 E9Q287
RefSeq (mRNA) NM_014243 NM_001081401
RefSeq (protein) NP_055058 NP_001074870
Location (UCSC) Chr 4:
73.15 – 73.43 Mb
Chr 5:
89.67 – 89.88 Mb
PubMed search [1] [2]

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.[1][2]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues.[2]


  1. ^ Tang BL, Hong W (Apr 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. 
  2. ^ a b "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.220