ADAMTS4

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ADAM metallopeptidase with thrombospondin type 1 motif, 4
2RJP.png
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ADAMTS4 ; ADAMTS-2; ADAMTS-4; ADMP-1
External IDs OMIM603876 MGI1339949 HomoloGene36169 ChEMBL: 2318 GeneCards: ADAMTS4 Gene
EC number 3.4.24.82
RNA expression pattern
PBB GE ADAMTS4 gnf1h00067 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9507 240913
Ensembl ENSG00000158859 ENSMUSG00000006403
UniProt O75173 Q8BNJ2
RefSeq (mRNA) NM_005099 NM_172845
RefSeq (protein) NP_005090 NP_766433
Location (UCSC) Chr 1:
161.16 – 161.17 Mb
Chr 1:
171.25 – 171.26 Mb
PubMed search [1] [2]

A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.[1]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.[2]


Alternative names[edit]

  • Aggrecanase-1 (initial name reflecting its ability to cleave aggrecan)

References[edit]

  1. ^ Tang BL, Hong W (Apr 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461. 
  2. ^ "Entrez Gene: ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4". 

Further reading[edit]

  • Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases". Int. J. Biochem. Cell Biol. 33 (1): 33–44. doi:10.1016/S1357-2725(00)00061-3. PMID 11167130. 
  • Hirohata S (2002). "[ADAMTS family--new extracellular matrix degrading enzyme]". Seikagaku 73 (11): 1333–7. PMID 11831030. 
  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  • Tortorella MD, Burn TC, Pratta MA, et al. (1999). "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins". Science 284 (5420): 1664–6. doi:10.1126/science.284.5420.1664. PMID 10356395. 
  • Abbaszade I, Liu RQ, Yang F, et al. (1999). "Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family". J. Biol. Chem. 274 (33): 23443–50. doi:10.1074/jbc.274.33.23443. PMID 10438522. 
  • Hurskainen TL, Hirohata S, Seldin MF, Apte SS (1999). "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family". J. Biol. Chem. 274 (36): 25555–63. doi:10.1074/jbc.274.36.25555. PMID 10464288. 
  • Tortorella MD, Pratta M, Liu RQ, et al. (2000). "Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)". J. Biol. Chem. 275 (24): 18566–73. doi:10.1074/jbc.M909383199. PMID 10751421. 
  • Matthews RT, Gary SC, Zerillo C, et al. (2000). "Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member". J. Biol. Chem. 275 (30): 22695–703. doi:10.1074/jbc.M909764199. PMID 10801887. 
  • Tortorella M, Pratta M, Liu RQ, et al. (2000). "The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage". J. Biol. Chem. 275 (33): 25791–7. doi:10.1074/jbc.M001065200. PMID 10827174. 
  • Nakamura H, Fujii Y, Inoki I, et al. (2001). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". J. Biol. Chem. 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281. 
  • Mizui Y, Yamazaki K, Kuboi Y, et al. (2001). "Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene". Mol. Biol. Rep. 27 (3): 167–73. doi:10.1023/A:1007253930568. PMID 11254106. 
  • Sandy JD, Westling J, Kenagy RD, et al. (2001). "Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4". J. Biol. Chem. 276 (16): 13372–8. doi:10.1074/jbc.M009737200. PMID 11278559. 
  • Gao G, Westling J, Thompson VP, et al. (2002). "Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation". J. Biol. Chem. 277 (13): 11034–41. doi:10.1074/jbc.M107443200. PMID 11796708. 
  • Yamanishi Y, Boyle DL, Clark M, et al. (2002). "Expression and regulation of aggrecanase in arthritis: the role of TGF-beta". J. Immunol. 168 (3): 1405–12. PMID 11801682. 
  • Westling J, Fosang AJ, Last K, et al. (2002). "ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain". J. Biol. Chem. 277 (18): 16059–66. doi:10.1074/jbc.M108607200. PMID 11854269. 
  • Malfait AM, Liu RQ, Ijiri K, et al. (2002). "Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage". J. Biol. Chem. 277 (25): 22201–8. doi:10.1074/jbc.M200431200. PMID 11956193. 

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.221