ADAMTS8

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ADAM metallopeptidase with thrombospondin type 1 motif, 8
Identifiers
Symbols ADAMTS8 ; ADAM-TS8; METH2
External IDs OMIM605175 MGI1353468 HomoloGene5108 GeneCards: ADAMTS8 Gene
Orthologs
Species Human Mouse
Entrez 11095 30806
Ensembl ENSG00000134917 ENSMUSG00000031994
UniProt Q9UP79 P57110
RefSeq (mRNA) NM_007037 NM_013906
RefSeq (protein) NP_008968 NP_038934
Location (UCSC) Chr 11:
130.27 – 130.3 Mb
Chr 9:
30.94 – 30.96 Mb
PubMed search [1] [2]

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.[1][2]

Function[edit]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.[2]

Clinical significance[edit]

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.[2]

References[edit]

  1. ^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (Sep 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512. 
  2. ^ a b c "Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: M12.226

This article incorporates text from the United States National Library of Medicine, which is in the public domain.