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ADAMTS-like 1
External IDs OMIM609198 MGI1924989 HomoloGene64642 GeneCards: ADAMTSL1 Gene
RNA expression pattern
PBB GE ADAMTSL1 gnf1h01179 at tn.png
More reference expression data
Species Human Mouse
Entrez 92949 77739
Ensembl ENSG00000178031 ENSMUSG00000066113
UniProt Q8N6G6 Q8BLI0
RefSeq (mRNA) NM_001040272 NM_029967
RefSeq (protein) NP_001035362 NP_084243
Location (UCSC) Chr 9:
18.47 – 18.91 Mb
Chr 4:
86.05 – 86.43 Mb
PubMed search [1] [2]

ADAMTS-like protein 1 is a protein that in humans is encoded by the ADAMTSL1 gene.[1][2][3]

This gene encodes a secreted protein resembling members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the propeptide region and the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]


  1. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581. 
  2. ^ Hirohata S, Wang LW, Miyagi M, Yan L, Seldin MF, Keene DR, Crabb JW, Apte SS (Apr 2002). "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix". J Biol Chem 277 (14): 12182–9. doi:10.1074/jbc.M109665200. PMID 11805097. 
  3. ^ a b "Entrez Gene: ADAMTSL1 ADAMTS-like 1". 

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