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Adenosine deaminase, RNA-specific, B2 (non-functional)
Symbols ADARB2 ; ADAR3; RED2
External IDs OMIM602065 MGI2151118 HomoloGene10276 GeneCards: ADARB2 Gene
RNA expression pattern
PBB GE ADARB2 220648 at tn.png
More reference expression data
Species Human Mouse
Entrez 105 94191
Ensembl ENSG00000185736 ENSMUSG00000052551
UniProt Q9NS39 Q9JI20
RefSeq (mRNA) NM_018702 NM_001289530
RefSeq (protein) NP_061172 NP_001276459
Location (UCSC) Chr 10:
1.23 – 1.78 Mb
Chr 13:
8.2 – 8.77 Mb
PubMed search [1] [2]

Double-stranded RNA-specific editase B2 is an enzyme that in humans is encoded by the ADARB2 gene.[1][2][3]


RNA-editing deaminase-2 (RED2, or ADARB2) is a member of the double-stranded RNA (dsRNA) adenosine deaminase family of RNA-editing enzymes. Adenosine deamination of pre-mRNA results in a change in the amino acid sequence of the gene product, which differs from that predicted by the genomic DNA sequence. Other members of this family include DRADA (ADAR) and RED1 (ADARB1).[3][1]

Unlike ADAR1 and ADAR2, ADAR3 has demonstrated no editing ability in vitro. It has been shown to suppress 5-HT2C RNA editing in vitro through a yet unknown mechanism, and may thus work as a negative regulator.[4]


  1. ^ a b Mittaz L, Antonarakis SE, Higuchi M, Scott HS (Sep 1997). "Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15". Human Genetics 100 (3-4): 398–400. doi:10.1007/s004390050523. PMID 9272162. 
  2. ^ Chen CX, Cho DS, Wang Q, Lai F, Carter KC, Nishikura K (May 2000). "A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains". RNA 6 (5): 755–67. doi:10.1017/S1355838200000170. PMC 1369955. PMID 10836796. 
  3. ^ a b "Entrez Gene: ADARB2 adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)". 
  4. ^ Hong HQ, Lin JS, Chen L (Feb 2015). "Regulatory factors governing Adenosine-to-Inosine (A-to-I) RNA editing". Bioscience Reports. doi:10.1042/BSR20140190. PMID 25662729. 

Further reading[edit]