ADCY1

Adenylate cyclase 1 (brain)
Identifiers
Symbols	ADCY1;
External IDs	OMIM: 103072 MGI: 99677 HomoloGene: 41419 GeneCards: ADCY1 Gene
EC number	4.6.1.1
Gene Ontology Molecular function • nucleotide binding • adenylate cyclase activity • calmodulin binding • ATP binding • calcium- and calmodulin-responsive adenylate cyclase activity • metal ion binding Cellular component • plasma membrane • plasma membrane • plasma membrane • integral to membrane Biological process • energy reserve metabolic process • cAMP biosynthetic process • cAMP biosynthetic process • water transport • activation of adenylate cyclase activity by G-protein signaling pathway • inhibition of adenylate cyclase activity by G-protein signaling pathway • activation of phospholipase C activity • synaptic transmission • axonogenesis • long-term memory • activation of protein kinase A activity • intracellular signal transduction • nerve growth factor receptor signaling pathway • transmembrane transport • cellular response to glucagon stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	107	432530
Ensembl	ENSG00000164742	ENSMUSG00000020431
UniProt	Q08828	Q5DTQ1
RefSeq (mRNA)	NM_021116	NM_009622.1
RefSeq (protein)	NP_066939	NP_033752.1
Location (UCSC)	Chr 7: 45.61 – 45.76 Mb	Chr 11: 6.96 – 7.08 Mb
PubMed search	[1]	[2]

Adenylate cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.

This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.

Further reading

• Osawa S, Dhanasekaran N, Woon CW, Johnson GL (1990). "G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions". Cell 63 (4): 697–706. doi:10.1016/0092-8674(90)90136-3. PMID 2121366. 
• Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes". Hum. Genet. 94 (5): 527–9. doi:10.1007/BF00211020. PMID 7959689. 
• Whisnant RE, Gilman AG, Dessauer CW (1996). "Interaction of the two cytosolic domains of mammalian adenylyl cyclase". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6621–5. doi:10.1073/pnas.93.13.6621. PMC 39075. PMID 8692867. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39075. 
• Barcova M, Speth C, Kacani L et al (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflugers Arch. 437 (4): 538–46. doi:10.1007/s004240050815. PMID 10089566. 
• Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS 14 (6): 629–36. doi:10.1097/00002030-200004140-00001. PMID 10807185. 
• Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179. 
• Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". J. Neurochem. 77 (2): 399–407. doi:10.1046/j.1471-4159.2001.00249.x. PMID 11299302. 
• Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. doi:10.1210/jc.86.9.4495. PMID 11549699. 
• Speth C, Schabetsberger T, Mohsenipour I et al (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". J. Virol. 76 (7): 3179–88. doi:10.1128/JVI.76.7.3179-3188.2002. PMC 136041. PMID 11884542. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=136041. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". J. Recept. Signal Transduct. Res. 22 (1–4): 79–110. doi:10.1081/RRS-120014589. PMID 12503609. 
• Scherer SW, Cheung J, MacDonald JR et al (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Tucholski J, Johnson GV (2003). "Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation". J. Biol. Chem. 278 (29): 26838–43. doi:10.1074/jbc.M303683200. PMID 12743114. 
• Hillier LW, Fulton RS, Fulton LA et al (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Wang H, Ferguson GD, Pineda VV et al (2004). "Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP". Nat. Neurosci. 7 (6): 635–42. doi:10.1038/nn1248. PMID 15133516. 
• Vortherms TA, Nguyen CH, Berlot CH, Watts VJ (2005). "Using molecular tools to dissect the role of Galphas in sensitization of AC1". Mol. Pharmacol. 66 (6): 1617–24. doi:10.1124/mol.104.000166. PMID 15361543. 
• Weber B, Schaper C, Scholz J et al (2006). "Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase". Cell. Signal. 18 (10): 1748–57. doi:10.1016/j.cellsig.2006.01.017. PMID 16531006. 
• Nlend MC, Schmid A, Sutto Z et al (2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Lett. 581 (17): 3241–6. doi:10.1016/j.febslet.2007.06.015. PMC 1986749. PMID 17586501. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1986749.