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Alcohol dehydrogenase 1A (class I), alpha polypeptide
Protein ADH1A PDB 1deh.png
PDB rendering based on 1deh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ADH1A ; ADH1
External IDs OMIM103700 HomoloGene88335 ChEMBL: 1970 GeneCards: ADH1A Gene
EC number
RNA expression pattern
PBB GE ADH1A 207820 at tn.png
More reference expression data
Species Human Mouse
Entrez 124 n/a
Ensembl ENSG00000187758 n/a
UniProt P07327 n/a
RefSeq (mRNA) NM_000667 n/a
RefSeq (protein) NP_000658 n/a
Location (UCSC) Chr 4:
100.2 – 100.21 Mb
PubMed search [1] n/a

Alcohol dehydrogenase 1A is an enzyme that in humans is encoded by the ADH1A gene.[1][2]

This gene encodes class I alcohol dehydrogenase, alpha subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. This gene is monomorphic and predominant in fetal and infant livers, whereas the genes encoding beta and gamma subunits are polymorphic and strongly expressed in adult livers.[2]


  1. ^ Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Adv Hum Genet 15: 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456. 
  2. ^ a b "Entrez Gene: ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide". 

Further reading[edit]