ADIPOR1

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Adiponectin receptor 1
Identifiers
Symbols ADIPOR1 ; ACDCR1; CGI45; PAQR1; TESBP1A
External IDs OMIM607945 MGI1919924 HomoloGene69199 IUPHAR: Adipo1 GeneCards: ADIPOR1 Gene
RNA expression pattern
PBB GE ADIPOR1 217748 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51094 72674
Ensembl ENSG00000159346 ENSMUSG00000026457
UniProt Q96A54 Q91VH1
RefSeq (mRNA) NM_001127687 NM_028320
RefSeq (protein) NP_057083 NP_082596
Location (UCSC) Chr 1:
202.91 – 202.93 Mb
Chr 1:
134.42 – 134.43 Mb
PubMed search [1] [2]

Adiponectin receptor 1, also known as ADIPOR1, is a protein which in humans is encoded by the ADIPOR1 gene.[1]

Structure[edit]

Similar to G protein-coupled receptors (GPCRs), ADIPOR1 also possesses 7 transmembrane domains. However ADIPOR1 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.[1]

Function[edit]

The adiponectin receptors, ADIPOR1 (this protein) and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.[1][2]

References[edit]

  1. ^ a b c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337. 
  2. ^ "Entrez Gene: ADIPOR1 adiponectin receptor 1". 

Further reading[edit]