ADP-specific glucokinase

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ADP-specific glucokinase
Identifiers
EC number 2.7.1.147
CAS number 173585-07-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
ADP-dependent glucokinase
Identifiers
Symbols ADPGK ; 2610017G09Rik; ADP-GK
External IDs OMIM611861 MGI1919391 HomoloGene41739 GeneCards: ADPGK Gene
EC number 2.7.1.147
Orthologs
Species Human Mouse
Entrez 83440 72141
Ensembl ENSG00000159322 ENSMUSG00000025236
UniProt Q9BRR6 Q8VDL4
RefSeq (mRNA) NM_031284 NM_028121
RefSeq (protein) NP_112574 NP_082397
Location (UCSC) Chr 15:
73.04 – 73.08 Mb
Chr 9:
59.29 – 59.32 Mb
PubMed search [1] [2]

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction

ADP + D-glucose \rightleftharpoons AMP + D-glucose 6-phosphate

Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.

This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.[1]

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GC5.

References[edit]

  1. ^ Ronimus RS, Morgan HW (March 2004). "Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase". Biochem. Biophys. Res. Commun. 315 (3): 652–8. doi:10.1016/j.bbrc.2004.01.103. PMID 14975750. 

Further reading[edit]